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Matsubara VH. Experimental oral colonization by Candida albicans in immunosuppressed mice treated with Lactobacillus acidophilus and Lactobacillus rhamnosus [dissertation] São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2011. To evaluate experimental oral candidiasis and the treatment using probiotics, 152 DBA/2 mice after being immunosuppressed were orally inoculated with a suspension of C. albicans containing 10 viable cells of yeast. The animals were devided into four groups: positive control (untreated), trated oraly with nystatin, with Lactobacillus acidophilus and with Lactobacillus rhamnosus. In the group that received nystatin, the treatment was initiated one day after Candida inoculation, and in the groups that received the probiotic bacteria, the treatment began fourteen days before inoculation. Treatments with nystatin and probiotics were daily and lasted 13 days. Evaluations were performed at 1, 3, 5, 7, 9, 11 and 13 days (after the initial inoculation) and made by microbiological analysis of the oral mucosa of these animals. The colonization of C. albicans in the oral mucosa animals began one day after the initial challenge and it was progressive and significant until the seventh day, when there was a significant reduction in the isolation of yeast. All treatments with probiotic bacteria significantly reduced the colonization of C. albicans in oral mucosa of the animals, compared to the untreated animal group. In group treated with L. rhamnosus the reduction of colonization of yeast was significantly higher compared to the group receiving nystatin. Based on the findings of this study we suggest that animal model DBA/2 immunosuppressed is a good model for experimental oral candidiasis and the treatment with probiotics in this model may be an effective alternative to the treatment of oral candidiasis.

Colonização oral experimental por Candida albicans em camundongos imunossuprimidos e tratados com Lactobacillus acidophilus e Lactobacillus rhamnosus