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PARENTE, J.M. Proteolytic actions of matrix metalloproteinase (MMP) -2 in morphological and vascular changes of resistance and conductance arteries in renovascular hypertension. 2017. 79 fls. Dissertação (Mestrado) – Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2017. Hypertension is a global public health problem that lead to significant vascular changes. Among them, the chronic remodeling and increased activity of matrix metalloproteinase (MMP)-2, which is responsible for extracellular matrix proteolysis, are the main mediators of the vascular maladaptation. During vascular remodeling, there is a change in the phenotype of vascular smooth muscle cells (VSMC) of contractile to synthetic form, with a reduction of contractile proteins such as calponin-1. This phenotype switch provides to the VSMC the ability of migration and proliferation, thus contributing to hypertension-induced arterial remodeling. Calponin-1 was degraded by MMP-2 in rat endotoxemic aortas and this effect contributed to the vascular hypocontractility. In addition, its reduction was associated with increased activity of MMP-2 and proliferation of VSMC in aortas of rats submitted to renovascular hypertension. Therefore, the hypothesis of this study is that MMP-2 contributes to hypertension-induced morphological and functional changes in conductance and resistance arteries by regulating calponin-1. To test such hypothesis, male Wistar rats were submitted to the two kidneyone clipe (2K-1C) hypertension model and were treated with doxycycline (inhibitor of MMPs activity at 30 mg/kg/day) or water for one week. Systolic blood pressure (SBP) was daily checked by tail-cuff plethysmography. Aortas and mesenteric arteries were

Ações proteolíticas da metaloproteinase de matriz (MMP)-2 nas alterações morfofuncionais de artérias de resistência e de condutância na hipertensão renovascular