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The scientific work is devoted to the urgent problem of our time - dishormonal disease of the female reproductive system, namely endometriosis and fibrosis-cystic mastitis. During the last years there has been a steady increase in the dual pathology of genital and breast diseases. According to statistics dishormonal frequency of breast diseases in the population of the female population suffering from various gynecological diseases varies between 76-98 %. It is known that the risk of this disease is closely associated with some alleles detoxification system, glutathione family - S- transferase and proonkogenom p 53, characterized by significant polymorphism. The article presents the results of research on the role of deletion variants of genes GSTT1, GSTM1 and p 53 in the development of endometriosis and fibrosis-cystic mastitis. Screening populations on carriage of alleles reveals women who are likely to develop these diseases and choose the most effective tactics of medical treatment in the event of the disease.

ВИЗНАЧЕННЯ ОСОБЛИВОСТЕЙ ГЕНОТИПІВ У ЖІНОК З ГЕНІТАЛЬНИМ ЕНДОМЕТРІОЗОМ ТА ФІБРОЗНО-КІСТОЗНОЮ МАСТОПАТІЄЮ ТА ЇХ РОЛЬ У ТЯЖКОСТІ ПЕРЕБІГУ ЗАХВОРЮВАННЯ