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The aim of the work: to analyze the frequency of polymorphic variants of genes BCL-2 ( rs 17759659), CTLA-4 ( rs 231775), APO-1/ Fas (rs 2234767) in patients, operated on nodular thyroid pathology with regard to its form (NGAIT, TA- thyroid adenoma). Materials and Methods. An analysis of the frequency of polymorphic variants of genes BCL-2 ( rs 17759659), CTLA-4 ( rs 231775), APO-1/Fas (rs 2234767) in 125 patients, operated on nodular thyroid pathology with regard to its form (NGAIT, TA) was conducted. Also, we examined 25 healthy donors. The study of polymorphism of genes was carried out by the method of polymerase chain reac­tion in real time. Results and Discussion. Mutation of BCL-2 gene ( rs 17759659) and CTLA-4 ( rs 231775) in the homozygous state among patients, operated on nodular thyroid pathology occurs with a frequency 3.2–4.0 % no reliable difference between patients with thyroid pathology and healthy. Mutation of the gene APO-1/Fas ( rs 2234767) in the homozygous state among surveyed patients was not met at all.

Поліморфізм генів apo-1 / fas, ctla-4 та bcl-2 у пацієнтів, оперованих із приводу вузлової патології щитоподібної залози