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Agency for Hemophilia and Regional Reference Center for Inherited Bleeding Disorders, Azienda Ospedaliariero – Universitaria Careggi, Florence, Italy; The National Haemophilia Centre, Institute of Haematology and Blood Transfusion, University Hospital, Bratislava, Slovakia; University of Ferrara, Medical School, Ferrara, Italy; Klinikum Bremen-Mitte, Professor Hess Children’s Hospital, Bremen, Germany; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy; National Institute of Statistics, Palermo, Italy; Laboratory of Hematology, University Hospital, Montpellier, France; Centre for Hemophilia and Thrombosis, Aarhus University Hospital, Skejby, Aarhus, Denmark; National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Israel; University of Palermo, Haematology Unit, Thrombosis and Hemostasis Reference Regional Center, Palermo, Italy

thrombosis and haemostasis

Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect