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Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been shown to occur in ACTH-secreting pituitary adenomas, thus calling attention to the ubiquitin system in corticotrope adenomas.

neuroendocrinology

&lt;b&gt;&lt;i&gt;Ubiquitin-Specific Protease 8&lt;/i&gt;&lt;/b&gt; Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing