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A-factor, a γ-butyrolactone autoregulator, in Streptomyces griseus is involved in the regulation of differentiation and antibiotic production. Here we studied the S. griseus B2682-AFN (A-factor negative) bald mutant that harbors a nonsense mutation in the afsR gene encoding a pleiotropic regulator. Our aim was to prove that this mutation is the cause of the A-factor deficiency in AFN. We also studied whether AfsR regulates A-factor production by AfsA, which is supposed to be the only specific key enzyme in A-factor biosynthesis.

microbial physiology

Mutation in &lt;b&gt;&lt;i&gt;afsR&lt;/i&gt;&lt;/b&gt; Leads to A-Factor Deficiency in &lt;b&gt;&lt;i&gt;Streptomyces griseus&lt;/i&gt;&lt;/b&gt; B2682