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Clostridium difficile infection (CDI) frequently complicates ulcerative colitis (UC) and can mimic disease flare. Differentiating UC flare from CDI remains a clinical challenge, particularly due to C. difficile colonization. Procalcitonin (PCT) is a serum biomarker for bacterial infections. We hypothesized that PCT would differentiate acute CDI from UC flare and C. difficile colonization.

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Differentiating &lt;b&gt;&lt;i&gt;Clostridium difficile&lt;/i&gt;&lt;/b&gt; Colitis from &lt;b&gt;&lt;i&gt;Clostridium difficile&lt;/i&gt;&lt;/b&gt; Colonization in Ulcerative Colitis: A Role for Procalcitonin?