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Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn.

neonatology

Effect of Concurrent Src Kinase Inhibition with Short-Duration Hypothermia on Ca&lt;sup&gt;2+&lt;/sup&gt;/Calmodulin Kinase IV Activity and Neuropathology after Hypoxia-Ischemia in the Newborn Swine Brain