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Objective:   To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in patients with psoriasis in a Turkish cohort.   Subjects and Methods:   In this case-control study, 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from the dermatology outpatient clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR was used to determine  GSTM1  and  GSTT1  polymorphisms in the isolated DNAs.   Results:   Of the 150 patients with psoriasis, 83 (79%) were identified with the GSTT1 genotype and 22 (21%) with the  null  genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype and 33 (32.4%) with the  null  genotype. There was no significant difference between the patient and control groups (p = 0.063). Regarding the  GSTM1  polymorphism, 54 (51.4%) patients were identified with this genotype and 51 (48.6%) with the  null  genotype; in the control group, 50 (49%) were identified with this genotype and 52 (51%) with the  null  genotype. Again there was no statistically significant difference between the groups (p = 0.957).   Conclusion:   In this Turkish cohort of patients with psoriasis, neither  GSTT1  nor  GSTM1  polymorphisms were associated with disease susceptibility. Larger studies with a wider range of GST isoenzyme are needed.

Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Psoriasis: A Case-Control Study