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In African Americans (AAs), APOL1 G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern. Additional risk and protective genetic variants may be present near the APOL1 loci, since earlier age ESKD is observed in some AAs with one APOL1 renal-risk variant, and because the adjacent gene MYH9 is associated with nephropathy in populations lacking G1 and G2 variants.

american journal of nephrology

Re-Sequencing of the &lt;b&gt;&lt;i&gt;APOL1&lt;/i&gt;&lt;/b&gt;-&lt;b&gt;&lt;i&gt;APOL4&lt;/i&gt;&lt;/b&gt; and &lt;b&gt;&lt;i&gt;MYH9&lt;/i&gt;&lt;/b&gt; Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression