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Objectives:   We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral  Candida dubliniensis  isolates to the surface of acrylic dentures.   Methods:   After determining the minimum inhibitory concentration of each drug, 20 oral isolates of  C. dubliniensis  were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay.   Results:   Compared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of  C. dubliniensis  isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p  <  0.001 for all drugs), respectively.   Conclusions:   Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of  C. dubliniensis  oral isolates to acrylic denture surfaces.

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In vitro Adhesion of Oral   Candida dubliniensis   Isolates to Acrylic Denture Surfaces following Brief Exposure to Sub-Cidal Concentrations of Polyenes, Azoles and Chlorhexidine