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Growth of E. coli on several carbon sources is dependent on the catabolite repressor/activator (Cra) protein although a Cra consensus DNA-binding site is not present in the control regions of the relevant catabolic operons. We show that Cra regulates growth by activating expression of the crp gene. It thereby mediates catabolite repression of catabolic operons by an indirect mechanism.

microbial physiology

Regulation of &lt;b&gt;&lt;i&gt;crp&lt;/i&gt;&lt;/b&gt; Gene Expression by the Catabolite Repressor/Activator, Cra, in &lt;b&gt;&lt;i&gt;Escherichia coli&lt;/i&gt;&lt;/b&gt;