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After careful review of the article entitled ‘Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer’s disease and other dementias’ [1] , we have identified significant inaccuracies that we believe warrant attention and should be addressed. A significant error is evident in figure 5. The numbers for the study that had been published by Tariot et al. [2] , DPZ + MEM 4.41 and DPZ + PBO 4.66, are correct, but since the range of the Clinician’s Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) scale goes from 1 to 7 with 7 being worst, the difference of –0.25 is in favor of experimental treatment and not as shown here in favor of the control. Additionally, the SD values for the MD-02 study are wrong. It seems that there may have been a mistake when calculating the SD from the SE values published in table 2 in the paper of Tariot et al. Both SDs are 1.05. This figure should be corrected to accurately portray the data reflecting the impact of combination therapy. Figure 5 in Muayqil and Camicioli [1] : Published online: May 20, 2014 E X T R A

dementia and geriatric cognitive disorders. extra

Important Error in ‘Systematic Review and Meta-Analysis of Combination Therapy with Cholinesterase Inhibitors and Memantine in Alzheimer's Disease and Other Dementias' by Muayqil and Camicioli