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The probiotic bacterial strain Escherichia coli Nissle 1917 (EcN) is used for the treatment of ulcerative colitis (UC), diarrhea and constipation. Its beneficial effects in the treatment of UC have been demonstrated in several controlled clinical studies; however, the mechanism of action on the cellular level is still not completely clear. The intracellular pattern recognition receptor NLRP3 is expressed in intestinal epithelial cells (IEC), activates caspase-1 within the inflammasome complex and has been implicated to play a role in the etiology of inflammatory bowel diseases.

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Probiotic &lt;b&gt;&lt;i&gt;Escherichia coli&lt;/i&gt;&lt;/b&gt; Nissle 1917 and Commensal &lt;b&gt;&lt;i&gt;E. coli&lt;/i&gt;&lt;/b&gt; K12 Differentially Affect the Inflammasome in Intestinal Epithelial Cells