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Objective:   To investigate the role of ultrasound guidance in intrauterine insemination (IUI).   Materials and Methods:   A retrospective study was conducted. The data was collected from the records of 197 couples with unexplained infertility who underwent IUI with a total of 267 IUI cycles in the in vitro fertilization center of our hospital between January 2009 and December 2010.   Results:   Of the 267 IUI cycles, 145 were carried out as US-guided, while 122 cycles IUI were performed with a blind procedure. In the US-guided IUI and blinded IUI groups, the pregnancy rates were 23.4 and 13.9%, respectively. The difference between the groups was statistically significant (p = 0.049), thereby indicating that US guidance improves pregnancy rates. In the US-guided IUI group, 9.7% of the cases were difficult, while in the blinded IUI group, 26.2% were difficult and the difference between the groups was also statistically significant (p < 0.001).   Conclusion:   US guidance in IUI improves pregnancy rates and reduces the frequency of difficult IUI.

The Use of Ultrasound during Intrauterine Insemination in Unexplained Infertility May Improve Pregnancy Outcomes