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The sodium/bicarbonate transporter NBCn1 plays an essential role in intracellular pH regulation and transepithelial HCO(3)(-) movement in the body. NBCn1 also has sodium channel-like activity uncoupled to Na/HCO(3) cotransport. We previously reported that NBCn1 interacts with the postsynaptic density protein PSD-95 in the brain. Here, we elucidated the structural determinant and functional consequence of NBCn1/PSD-95 interaction.

PSD-95 Interacts with NBCn1 and Enhances Channel-like Activity without Affecting Na/HCO3Cotransport

PSD-95 Interacts with NBCn1 and Enhances Channel-like Activity without Affecting Na/HCO₃Cotransport