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The pathogenesis of Alzheimer's disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-β and secondary vessel degeneration. In the polycystic kidney disease (PKD) rat model, we observed neuronal injury, microglial activation and vasoregression. We speculated that this neuroretinal degeneration shares important pathogenetic steps with AD. Therefore, we determined the activation of astrocytes and the accumulation of amyloid-β in PKD retinae.

Alzheimers Disease and Retinal Neurodegeneration Share a Consistent Stress Response of the Neurovascular Unit

Alzheimers Disease and Retinal Neurodegeneration Share a Consistent Stress Response of the Neurovascular Unit