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Migration of dendritic cells (DCs), antigen presenting cells that link innate and adaptive immunity, is critical for initiation of immune responses. DC migration is controlled by the activity of different ion channels, which mediate Ca(2+) flux or set the membrane potential. Moreover, cell migration requires local volume changes at the leading and rear end of travelling cells, which might be mediated by the fluxes of osmotically active solutes, including Cl(-). The present study explored the functional expression, regulation and role of Cl(-) channels in mouse bone marrow-derived DCs.

Expression and Functional Significance of the Ca2+-Activated Cl-Channel ANO6 in Dendritic Cells

Expression and Functional Significance of the Ca²⁺-Activated Cl^-Channel ANO6 in Dendritic Cells