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Dupuytren's disease (DD) is a nodular palmar fibromatosis that causes irreversible permanent contracture of fingers and results in the loss of hand function. Surgery still remains the only available solution for DD patients but cannot permanently cure the disease nor reduce high recurrence rates. With this rationale, we designed a study aimed at an improved understanding of the molecular mechanisms underlying DD. Our major focus was an analysis of the global gene expression profile and signalling pathways in DD cells with the aim of identifying novel biomarkers and/or therapeutic targets.

Microarray Analysis of Dupuytrens Disease Cells: The Profibrogenic Role of the TGF-� Inducible p38 MAPK Pathway

Microarray Analysis of Dupuytrens Disease Cells: The Profibrogenic Role of the TGF-� Inducible p38 MAPK Pathway