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The present study was conducted to investigate the renal tubular handling of inorganic cadmium (Cd(2+)) by exposing primary human tubular cell cultures to physiologically relevant doses of cadmium chloride (CdCl(2)). Furthermore, the cellular accumulation of Cd(2+) was compared to that of metallothionein-1-bound Cd (Cd7MT-1). Finally, this study aimed to investigate the effect of the accumulation of Cd (both Cd(2+) and Cd7MT-1) in renal cells on the expression of genes relevant to nephrotoxic processes.

nephron extra

Low Doses of Cadmium Chloride and Methallothionein-1-Bound Cadmium Display Different Accumulation Kinetics and Induce Different Genes in Cells of the Human Nephron