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Oxidative stress has been proposed as a major contributing factor for vascular disease, that acts independently from its participation in predisposing disorders such as diabetes and arterial hypertension. A functionally relevant C242T polymorphism of the CYBA gene encoding the NAD(P)H oxidase p22(phox) subunit, is supposed to lead to an abnormal reduction in the generation of reactive oxygen species in vascular smooth-muscle and endothelial cells.

cerebrovascular diseases

The C242T Polymorphism of the NAD(P)H Oxidase p22&lt;sup&gt;phox&lt;/sup&gt; Subunit Is Associated with an Enhanced Risk for Cerebrovascular Disease at a Young Age