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The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252.

kidney and blood pressure research

Effect of a Selective Endothelin Receptor A Blocker on Cardiovascular Remodeling in Uninephrectomized Spontaneously Hypertensive Rats of the Stroke-Prone Strain