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Modeling means replacing a complicated mechanism by a simpler one that is more easy to understand and/or to manipulate. The complexity of the hemostatic and thrombotic system (H&TS) is such that it is impossible to understand without modeling. The Quick-time is a model of the downregulation of the H&TS by oral anticoagulation or liver disease. The bleeding time is another model of another subsystem of the H&TS, with another scope. This illustrates that models never are complete and that they do not need to be complete to be useful. Actually, the most complete models are usually also complex, time-consuming, expensive, and extremely diffi cult to interprete. Mathematical models are of a special kind (for a review of mathematical and computer research in coagulation, see [1] ). In the fi rst place they are impressive and impenetrable to the noninitiated – and the initiated are few. The biological scientist as a rule is not familiar with this approach. As soon as a biochemical mechanism is more complicated than the Michaelis-Menten model of enzyme action, many life-scientists and clinicians tend to be turned off, which is a pity because mathematical modeling is not an aim in itself, but should prove its value in the confrontation with actual laboratory data and needs the biologists for its verifi cation. This is one reason to broach mathematical modeling in a journal on patho

Good Mathematical Practice: Simulation of the Hemostatic-Thrombotic Mechanism, a Powerful Tool but One That Must Be Used with Circumspection