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The collectin surfactant protein A (SP-A) is involved in the innate host defense of the lung. It binds to non-self glyco-conjugates on the surface of invading microorganisms. Binding leads to lysis, aggregation and initiation of effector mechanisms that include increased phagocytosis by phagocytic cells and modulation of the inflammatory response (Haagsman, 2002). Across species, the gene encoding SP-A has been found in loci containing genes encoding other collectins. In humans, the collectin gene locus encodes SP-A, surfactant protein D (SP-D) and mannan-binding lectin (MBL) and it maps to chromosome 10q22.3. The genes encoding the bovine collectins conglutinin, collectin 43 (CL-43), collectin 46 (CL-46) and SP-D, have previously been linked to the microsatellites ILSTS099 and IDVGA-8 at chromosome 28 (BTA28) at position q1.8→q1.9 (Gallagher et al., 1993; Hansen et al., 2002, 2003; Gjerstorff et al. 2004). In the present mapping, we find that the gene encoding SP-A maps to the same locus on BTA28. Materials and methods

Assignment of the surfactant protein A gene (SFTPA) to bovine chromosome 28q1.8→q1.9 by radiation hybrid mapping