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Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation. In a number of FSGS patients, plasmapheresis and immunoadsorption procedures have been shown to transiently reduce proteinuria and are thought to do this by eliminating a circulating factor. Direct cellular effects of eluates from immunoadsorption procedures on podocytes, the primary target of injury in FSGS, have not yet been reported.

kidney and blood pressure research

Eluate Derived by Extracorporal Antibody-Based Immunoadsorption Elevates the Cytosolic Ca&lt;sup&gt;2+&lt;/sup&gt; Concentration in Podocytes via B&lt;sub&gt;2&lt;/sub&gt; Kinin Receptors