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Since antigen-specific IgE and eosinophils are major inducing factors of allergic inflammation of the airways, both factors are therapeutic targets of asthma. We investigated the effects of ONO-4007, a nontoxic lipid A analogue, on antigen-specific antibody response and the recruitment of eosinophils into airways in murine systems.

Lipid A Analogue, ONO-4007, Inhibits IgE Response and Antigen-Induced Eosinophilic Recruitment into Airways in BALB/c Mice