Open AccessRevealing ARID1A Function in Gastric Cancer from the Bottom Up
Author(s) -
María Paz Zafra,
Lukas E. Dow
Publication year - 2021
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-21-0271
Subject(s) - arid1a , cancer , context (archaeology) , cancer research , survivin , biology , loss function , wnt signaling pathway , function (biology) , computational biology , bioinformatics , gene , microbiology and biotechnology , mutation , genetics , phenotype , paleontology
Summary: In this issue of Cancer Discovery, Lo and colleagues use CRISPR-based genome engineering in primary human gastric organoids to reveal the functional consequences of ARID1A loss in the early stages of gastric cancer. They show that ARID1A disruption is not tolerated in wild-type organoids, but in the context of TP53 loss, leads to WNT suppression, mucinous metaplasia, enhanced tumorigenicity, and selectively toxicity to BIRC5/Survivin inhibition. See related article by Lo et al., p. 1562.
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