Open AccessMitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade
Author(s) -
Michael R. Savona,
Jeffrey C. Rathmell
Publication year - 2019
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-19-0510
Subject(s) - blockade , myeloid leukemia , function (biology) , crispr , myeloid , biology , cancer research , mitochondrion , cancer , leukemia , homeostasis , medicine , bioinformatics , microbiology and biotechnology , immunology , genetics , receptor , gene
Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of Cancer Discovery , two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition. See related article by Chen et al., p. 890 . See related article by Nechiporuk et al., p. 910 .
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