Open AccessJAK Mutations as Escape Mechanisms to Anti–PD-1 Therapy
Author(s) -
Aurélien Marabelle,
Sandrine Aspeslagh,
Sophie PostelVinay,
JeanCharles Soria
Publication year - 2017
Publication title -
cancer discovery
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-16-1439
Subject(s) - cancer , immunotherapy , mutation , cancer research , medicine , immune escape , biology , genetics , immunology , bioinformatics , gene
JAK mutations could be one of the primary escape mechanisms to anti-PD-1/PD-L1 immunotherapy via impaired IFNγ signaling in cancer cells and could be used to identify patients unlikely to benefit from these treatments. Cancer Discov; 7(2); 128-30. ©2017 AACR.See related article by Shin et al., p. 188.
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