Open AccessImmunotherapy and Oncogenic Pathways: The PTEN Connection
Author(s) -
Naiyer A. Rizvi,
Timothy A. Chan
Publication year - 2016
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-15-1501
Subject(s) - pten , connection (principal bundle) , immunotherapy , cancer research , computational biology , biology , cancer , signal transduction , genetics , pi3k/akt/mtor pathway , engineering , structural engineering
Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma. These results shed light on the intricate interplay between oncogenic pathways and antitumor immune response.
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