Open AccessRNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma
Author(s) -
Joshua C. Black,
Johnathan R. Whetstine
Publication year - 2015
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-15-1285
Subject(s) - carcinogenesis , cancer research , melanoma , dual (grammatical number) , biology , chemistry , gene , genetics , art , literature
RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.
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