Open AccessTurning Telomerase into a Jekyll and Hyde Case?
Author(s) -
Raymund J. Wellinger
Publication year - 2015
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-14-1346
Subject(s) - telomerase , telomere , guanine , dna , enzyme , nucleotide , chromosome , biochemistry , biology , microbiology and biotechnology , chemistry , genetics , gene
It may be possible to coerce telomerase to incorporate modified guanine nucleotides into telomeric repeat DNA, thereby seriously compromising the functionality of the telomeres. Thus, a guanine analogue such as 6-thio-dG could turn active telomerase into a chromosome de-protecting enzyme, the opposite of what it is normally, namely a chromosome-protecting enzyme.
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