Open AccessEpigenetic Approaches for Chemosensitization of Refractory Diffuse Large B-Cell Lymphomas
Author(s) -
James J. Steinhardt,
Ronald B. Gartenhaus
Publication year - 2013
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-13-0358
Subject(s) - epigenetics , diffuse large b cell lymphoma , lymphoma , dna methylation , cancer , cancer research , medicine , methyltransferase , disease , oncology , biology , methylation , dna , genetics , gene , gene expression
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, with the greatest challenge for improving patient survival being the management of chemorefractory disease upon relapse. Epigenetic dysregulation has been correlated with more-aggressive malignancies and chemoresistance. In this issue of Cancer Discovery, Clozel and colleagues show the potential for low-dose DNA methyltransferase inhibitors as both a rational and an effective neoadjuvant approach for chemosensitization in DLBCL.
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