Open AccessDéjà Vu: EGF Receptors Drive Resistance to BRAF Inhibitors
Author(s) -
María Romina Girotti,
Richard Marais
Publication year - 2013
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-13-0131
Subject(s) - cancer , thyroid cancer , cancer research , melanoma , medicine , oncogene , mutation , thyroid , receptor , signal transduction , bioinformatics , biology , gene , genetics , cell cycle
The promise of personalized medicine is upon us, and in some cancers, targeted therapies are rapidly becoming the mainstay of treatment for selected patients based on their molecular profile. The protein kinase BRAF is a driver oncogene in both thyroid cancer and melanoma, but while drugs that target BRAF and its downstream signaling pathway are effective in melanoma, they are ineffective in thyroid cancer. In this issue of Cancer Discovery, Montero-Conde and colleagues investigate why thyroid cancer is resistant to BRAF inhibitors despite the presence of BRAF mutation.
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