Open AccessA Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism
Author(s) -
Bárbara Martínez-Pastor,
Claudia Cosentino,
Raúl Mostoslavsky
Publication year - 2013
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-13-0059
Subject(s) - chromatin , epigenetics , histone , acetylation , dna methylation , biology , metabolism , energy metabolism , dna , microbiology and biotechnology , chromatin remodeling , epigenomics , computational biology , genetics , biochemistry , gene , gene expression , endocrinology
Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine.
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