Open AccessFingerprinting Acute Leukemia: DNA Methylation Profiling of B-Acute Lymphoblastic Leukemia
Author(s) -
Luisa Cimmino,
Iannis Aifantis
Publication year - 2012
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-12-0435
Subject(s) - epigenetics , dna methylation , gene expression profiling , cancer research , leukemia , lymphoblastic leukemia , methylation , cancer , gene , biology , acute lymphocytic leukemia , computational biology , medicine , genetics , gene expression
In this issue of Cancer Discovery, Geng and colleagues report on their use of a combination of promoter cytosine methylation profiling with gene expression and ChIP sequencing to elucidate molecular signatures of adult B-acute lymphoblastic leukemia patient samples with BCR-ABL1, E2A-PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases.
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