Open AccessHello Out There…Is Anybody Listening?
Author(s) -
Rosa Anna DeFilippis,
Thea D. Tlsty
Publication year - 2012
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-12-0434
Subject(s) - active listening , intervention (counseling) , tumor cells , primary (astronomy) , cancer research , medicine , primary tumor , biology , computational biology , bioinformatics , psychology , cancer , metastasis , communication , physics , psychiatry , astronomy
Using a murine xenograft model system, Kuznetsov and colleagues show the existence of systemic interactions between a primary tumor and the growth of distal tumors in both homotypic and heterotypic tissues. Importantly, they show that the characteristics of the primary tumor govern the histologic features of the distal tumor through distinct pathways, thus providing novel opportunities for risk assessment, prognosis, prevention, and intervention.
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