Open AccessUnderstanding the Lethal Variant of Prostate Cancer: Power of Examining Extremes
Author(s) -
Ana M. Aparicio,
Christopher J. Logothetis,
Sankar N. Maity
Publication year - 2011
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-11-0259
Subject(s) - prostate cancer , cancer research , cancer , kinase , oncogene , prostate , disease , biology , medicine , cell cycle , genetics
Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN proto-oncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset.
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