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To the Editor: We believe that the enthusiasm of Lance and Hamilton ([1][1]) in embracing the study by Cho et al. ([2][2]) as “seminal” and their finality in dismissing aberrant crypt foci (ACF) as a surrogate end point for chemoprevention trials are misplaced. We are concerned that the

cancer prevention research

Comment re: “Sporadic Aberrant Crypt Foci Are Not a Surrogate Endpoint for Colorectal Adenoma Prevention” and “Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial”