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• Hepatocellular Carcinoma (HCC) is a deadly tumor that spans more than 780,000 new diagnoses and causes 750,000 annual deaths worldwide. • Alcoholic liver disease represents a common progressive chronic liver ailment that incites liver cirrhosis—a precancerous state of liver scarring—that increases the risk for HCC development • The health status of the liver affects HCC tumor biology and treatment responses; therefore, a large animal model capable of exhibiting both HCC and alcohol induced liver cirrhosis would be a valuable resource for preclinical research investigating HCC in its native comorbid cirrhotic microenvironment. • Pigs represent ideal human disease models due to their similar size, anatomy, metabolism, genetics, and epigenetics compared to humans. • This study utilized the innovative Oncopig Cancer Model (OCM)-–a transgenic swine model that recapitulates human cancer through development of site and cell specific tumors via induced expression of heterozygous KRASG12D and TP53R167H transgenes—to develop alcohol induced fibrosis in a porcine model capable of developing HCC tumors. Introduction

cancer research

Abstract 2088: Characterization of an inducible alcoholic liver fibrosis model for hepatocellular carcinoma investigation in a transgenic porcine platform