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A model mimicking important clinical aspects of castration-resistant prostate cancer bone metastases was established. Tumor take and growth rates indicated that early phases of tumor development into the bone is androgen regulated whereas tumor growth at later stage relies on the bone microenvironment for growth support. The results highlight the significance of the tumor microenvironment in establishing clinically relevant preclinical models for drug development. Conclusions  A tumor take rate of 60%, 40% and 50% was observed in the intact mice and in the mice castrated one week before and four weeks after VCaP cell inoculation, respectively. Tumor take rate was determined based on evaluation of PSA, bone lesions by X-ray imaging, and histological findings.

Abstract 1162: Castration-resistant prostate cancer bone metastasis model to assess new therapeutics