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Patients with advanced renal cell cancer (RCC) have a poor prognosis not least because of resistance towards standard drugs. Recently, pronounced intratumoral heterogeneity (ITH) in RCC was shown. We were interested whether this ITH is a potential cause for treatment failure. We developed a large panel of patient-derived xenograft (PDX) models from RCC, including subsets of models from different regions of one individual patient tumor. The PDX models were evaluated for response to targeted standard therapeutics. To better understand correlations between interand intratumoral heterogeneity and treatment response, an explorative analysis of gene expression and panel sequencing data was performed.

Abstract 1843: Intratumoral heterogeneity of renal cancer is related to differences in drug response and development of therapy resistance