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Cross-reactivity with normal tissues is one of the key concerns for target selection for antibody-drug conjugates. Probody therapeutics are masked antibodies that can selectively be activated by proteases in the tumor. CX-2029, is a first-in-class Probody targeting CD71 with preliminary efficacy and a tolerable safety profile. See related article by Johnson et al., p. 4521 .

Unmasking New Promises: Expanding the Antigen Landscape For Antibody–Drug Conjugates