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Mogamulizumab, approved by the FDA for relapsed or refractory mycosis fungoides and Sézary syndrome, improves progression-free survival compared with vorinostat in the largest trial to date in cutaneous T-cell lymphoma, with particular efficacy in leukemic disease, but carries a risk of immune-mediated toxicities with concomitant depletion of regulatory T cells. See related article by Kasamon et al., p. 7275 .

Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem