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Ductal carcinoma in situ (DCIS) is a nonobligate precursor of invasive breast cancer. Here, we sought to investigate the level of intralesion genetic heterogeneity in DCIS and the patterns of clonal architecture changes in the progression from DCIS to invasive disease.

Whole-Exome Sequencing Analysis of the Progression from Non–Low-Grade Ductal CarcinomaIn Situto Invasive Ductal Carcinoma