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While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance. See related article by Lin et al., p. 6228 .

Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance