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Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen presentation and suggest a novel way to enhance the potency of existing anticancer agents. See related article by Jaeger et al., p. 6392 .

Low-Level Inhibition of Hsp90 Forces Cells to Tip Their (Antigenic) Hand