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Uveal melanoma is a primary malignancy of the eye with oncogenic mutations in GNAQ, GNA11, or CYSLTR2 , and additional mutations in BAP1 (usually associated with LOH of Chr 3), SF3B1 , or EIF1AX . There are other characteristic chromosomal alterations, but their significance is not clear.

clinical cancer research

Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for <i>PHF10/BAF45a</i>

Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role for PHF10/BAF45a