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Pazopanib+trametinib was tolerable at full single-agent doses with clinical activity in DTC but did not achieve the pre-specified response rate target.

clinical cancer research

A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers